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A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches

Emin Cam, M; Nur Hazar-Yavuz, A; Cesur, S; Ozkan, O; Alenezi, H; Turkoglu Sasmazel, H; Sayip Eroglu, M; ... Edirisinghe, M; + view all (2020) A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches. International Journal of Pharmaceutics , 588 , Article 119782. 10.1016/j.ijpharm.2020.119782. Green open access

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Abstract

Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.

Type: Article
Title: A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2020.119782
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2020.119782
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Progesterone, electrospinning, fibers, polymeric patch, pressurized gyration, preterm birth
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10108902
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