Ahmadi, D;
Mahmoudi, N;
Li, P;
Ma, K;
Doutch, J;
Foglia, F;
Heenan, RK;
... Lawrence, MJ; + view all
(2020)
Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream.
Scientific Reports
, 10
(1)
, Article 4082. 10.1038/s41598-020-61096-x.
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Abstract
Creams are multi-component semi-solid emulsions that find widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, and they also feature prominently in veterinary preparations and processed foodstuffs. The internal architectures of these systems, however, have to date been inferred largely through macroscopic and/or indirect experimental observations and so they are not well-characterized at the molecular level. Moreover, while their long-term stability and shelf-life, and their aesthetics and functional utility are critically dependent upon their molecular structure, there is no real understanding yet of the structural mechanisms that underlie the potential destabilizing effects of additives like drugs, anti-oxidants or preservatives, and no structure-based rationale to guide product formulation. In the research reported here we sought to address these deficiencies, making particular use of small-angle neutron scattering and exploiting the device of H/D contrast variation, with complementary studies also performed using bright-field and polarised light microscopy, small-angle and wide-angle X-ray scattering, and steady-state shear rheology measurements. Through the convolved findings from these studies we have secured a finely detailed picture of the molecular structure of creams based on Aqueous Cream BP, and our findings reveal that the structure is quite different from the generic picture of cream structure that is widely accepted and reproduced in textbooks.
| Type: | Article |
|---|---|
| Title: | Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-020-61096-x |
| Publisher version: | https://doi.org/10.1038/s41598-020-61096-x |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ANGLE NEUTRON-SCATTERING, X-RAY-SCATTERING, EMULSION, EMULSIFIERS, INTERFACE, BEHAVIOR, SYSTEMS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10108732 |
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