UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations

Fournier, J; Saleem, AB; Diamanti, EM; Wells, MJ; Harris, KD; Carandini, M; (2020) Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations. Current Biology 10.1016/j.cub.2020.07.006. Green open access

[thumbnail of 1-s2.0-S0960982220309969-main.pdf]
Preview
Text
1-s2.0-S0960982220309969-main.pdf - Published version

Download (1MB) | Preview

Abstract

Summary The visual responses of neurons in the primary visual cortex (V1) are influenced by the animal’s position in the environment [1, 2, 3, 4, 5]. V1 responses encode positions that co-fluctuate with those encoded by place cells in hippocampal area CA1 [2, 5]. This correlation might reflect a common influence of non-visual spatial signals on both areas. Place cells in CA1, indeed, do not rely only on vision; their place preference depends on the physical distance traveled [6, 7, 8, 9, 10, 11] and on the phase of the 6–9 Hz theta oscillation [12, 13]. Are V1 responses similarly influenced by these non-visual factors? We recorded V1 and CA1 neurons simultaneously while mice performed a spatial task in a virtual corridor by running on a wheel and licking at a reward location. By changing the gain that couples the wheel movement to the virtual environment, we found that ∼20% of V1 neurons were influenced by the physical distance traveled, as were ∼40% of CA1 place cells. Moreover, the firing rate of ∼24% of V1 neurons was modulated by the phase of theta oscillations recorded in CA1 and the response profiles of ∼7% of V1 neurons shifted spatially across the theta cycle, analogous to the phase precession observed in ∼37% of CA1 place cells. The influence of theta oscillations on V1 responses was more prominent in putative layer 6. These results reveal that, in a familiar environment, sensory processing in V1 is modulated by the key non-visual signals that influence spatial coding in the hippocampus.

Type: Article
Title: Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2020.07.006
Publisher version: https://doi.org/10.1016/j.cub.2020.07.006
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: primary visual cortex, hippocampus, navigation, distance coding, theta oscillation, virtual reality
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10108165
Downloads since deposit
21Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item