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Aggressive multiple sclerosis (2): Treatment

Arrambide, G; Iacobaeus, E; Amato, MP; Derfuss, T; Vukusic, S; Hemmer, B; Brundin, L; ... 2018 ECTRIMS Focused Workshop Group; + view all (2020) Aggressive multiple sclerosis (2): Treatment. Multiple Sclerosis Journal , 26 (9) pp. 1045-1063. 10.1177/1352458520924595. Green open access

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Abstract

The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.

Type: Article
Title: Aggressive multiple sclerosis (2): Treatment
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458520924595
Publisher version: http://dx.doi.org/10.1177/1352458520924595
Language: English
Additional information: https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Aggressive, disability, highly active, multiple sclerosis, relapsing–remitting, treatment response
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10108111
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