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Aggressive multiple sclerosis (1): Towards a definition of the phenotype

Iacobaeus, E; Arrambide, G; Pia Amato, M; Derfuss, T; Vukusic, S; Hemmer, B; Tintore, M; ... 2018 ECTRIMS Focused Workshop Group; + view all (2020) Aggressive multiple sclerosis (1): Towards a definition of the phenotype. Multiple Sclerosis Journal , 26 (9) pp. 1031-1044. 10.1177/1352458520925369. Green open access

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Abstract

While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management.

Type: Article
Title: Aggressive multiple sclerosis (1): Towards a definition of the phenotype
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458520925369
Publisher version: http://dx.doi.org/10.1177/1352458520925369
Language: English
Additional information: https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Aggressive, disability, highly active, multiple sclerosis, observational studies, relapsing/remitting
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10108110
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