Nyazika, TK;
Law, A;
Swarthout, TD;
Sibale, L;
ter Braake, D;
French, N;
Heyderman, RS;
... Neill, DR; + view all
(2020)
Influenza-like illness is associated with high pneumococcal carriage density in Malawian children.
Journal of Infection
10.1016/j.jinf.2020.06.079.
(In press).
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Abstract
BACKGROUND: High pneumococcal carriage density is a risk factor for invasive pneumococcal disease (IPD) and transmission, but factors that increase pneumococcal carriage density are still unclear. METHODS: We undertook a cross-sectional study to evaluate the microbial composition, cytokine levels and pneumococcal carriage densities in samples from children presenting with an influenza-like illness (ILI) and asymptomatic healthy controls (HC). RESULTS: The proportion of children harbouring viral organisms (Relative risk (RR) 1.4, p = 0.0222) or ≥ 4 microbes at a time (RR 1.9, p < 0.0001), was higher in ILI patients than HC. ILI patients had higher IL-8 levels in nasal aspirates than HC (median [IQR], 265.7 [0 - 452.3] vs. 0 [0 - 127.3] pg/ml; p = 0.0154). Having an ILI was associated with higher pneumococcal carriage densities compared to HC (RR 4.2, p < 0.0001). CONCLUSION: These findings suggest that children with an ILI have an increased propensity for high pneumococcal carriage density. This could in part contribute to increased susceptibility to IPD and transmission in the community.
| Type: | Article |
|---|---|
| Title: | Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jinf.2020.06.079 |
| Publisher version: | https://doi.org/10.1016/j.jinf.2020.06.079 |
| Language: | English |
| Additional information: | © 2020 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Carriage density, Children, IL-8, Influenza-like illness, Pneumococcal |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10108042 |
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