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Highly Sensitive Luminescence Detection of Photosensitized Singlet Oxygen within Photonic Crystal Fibers

Williams, GOS; Euser, TG; Russell, PSJ; MacRobert, AJ; Jones, AC; (2018) Highly Sensitive Luminescence Detection of Photosensitized Singlet Oxygen within Photonic Crystal Fibers. ChemPhotoChem , 2 (7) pp. 616-621. 10.1002/cptc.201800028. Green open access

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Abstract

Highly sensitive, quantitative detection of singlet oxygen (1O2) is required for the evaluation of newly developed photosensitizers and the elucidation of the mechanisms of many processes in which singlet oxygen is known or believed to be involved. The direct detection of 1O2 through its intrinsic phosphorescence at 1270 nm is challenging, because of the extremely low intensity of this emission, coupled with the low quantum efficiency of currently available photodetectors at this wavelength. We introduce hollow‐core photonic crystal fibers (HC‐PCF) as a novel optofluidic modality for photosensitization and detection of 1O2. We report the use of this approach to achieve highly sensitive detection of the luminescence decay of 1O2 produced by using two common photosensitizers, Rose Bengal and Hypericin, within the 60‐μm diameter core of a 15 cm length of HC‐PCF. We demonstrate the feasibility of directly detecting sub‐picomole quantities of 1O2 by using this methodology, and identify some aspects of the HC‐PCF technology that can be improved to yield even higher detection sensitivity.

Type: Article
Title: Highly Sensitive Luminescence Detection of Photosensitized Singlet Oxygen within Photonic Crystal Fibers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cptc.201800028
Publisher version: https://doi.org/10.1002/cptc.201800028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Chemistry, Physical, Chemistry, singlet oxygen, luminescence, photonic crystal fiber, photosensitization, lifetime, PHOTODYNAMIC THERAPY, MOLECULAR-OXYGEN, PROBE, PHOSPHORESCENCE, GENERATION, SURFACES, CANCER, CHARGE, STATE, DYES
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10108004
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