Ge, GM;
Leung, MTY;
Man, KKC;
Leung, WC;
Ip, P;
Li, GHY;
Wong, I;
... Cheung, C-L; + view all
(2020)
Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis.
Journal of Clinical Endocrinology and Metabolism
, 105
(12)
pp. 3821-3841.
10.1210/clinem/dgaa555.
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Abstract
Context: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective: To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources: PubMed, EMBASE, and Cochrane Library. Study Selections: Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction: Reviewers extracted data on study characteristics and results independently. Data Synthesis: Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results: We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring. Conclusion: Routine measurement and timely treatment on thyroid function should be considered for pregnant women.
| Type: | Article |
|---|---|
| Title: | Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1210/clinem/dgaa555 |
| Publisher version: | https://doi.org/10.1210/clinem/dgaa555 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | gestation, child development, offspring, pregnancy, thyroid, neurodevelopmental disorders |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10107765 |
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