Hall, C;
Potticary, J;
Hamilton, V;
Gaisford, S;
Buanz, A;
Hall, S;
(2020)
Metastable Crystalline Phase Formation in Deep Eutectic Systems Revealed by Simultaneous Synchrotron XRD and DSC.
Chemical Communications
10.1039/d0cc04696e.
(In press).
Preview |
Text
d0cc04696e.pdf - Accepted Version Download (1MB) | Preview |
Abstract
The phase behaviour of various deep eutectic systems was analysed using concurrent synchrotron powder X-ray diffraction and differential scanning calorimetry. Deep eutectic systems containing the pharmaceuticals metacetamol, 2-ethoxybenzamide or benzamide as binary mixtures with phenol revealed new crystalline phases melting either before or with crystals of phenol, highlighting their lower stabilities. Furthermore, in the phenol:2-ethoxybenzamide system it was shown that multiple metastable phases can form, highlighting the potential for the separation of a hierarchy of crystal structures with differing stabilities from eutectic systems. Through these experiments, we strengthen the idea that eutectic systems can be described by understanding the formation and stabilities of metastable co-crystalline structures. These novel results lead to a deeper understanding of the structure and thermodynamics of deep eutectic solvents, with relevance for analagous systems across materials science.
| Type: | Article |
|---|---|
| Title: | Metastable Crystalline Phase Formation in Deep Eutectic Systems Revealed by Simultaneous Synchrotron XRD and DSC |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d0cc04696e |
| Publisher version: | https://doi.org/10.1039/D0CC04696E |
| Language: | English |
| Additional information: | © Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10107475 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
