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Psychosocial factors influencing adherence to iron chelation therapy in patients with thalassaemia

Cobner, Rhiannon; (1999) Psychosocial factors influencing adherence to iron chelation therapy in patients with thalassaemia. Doctoral thesis (D.Clin.Psy), UCL (University College London). Green open access

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Abstract

This study investigated a number of psychosocial factors and their relationship to nonadherence to iron chelation therapy in patients with thalassaemia. The quantitative component aimed to examine the relationship between non-adherence and psychological distress, well-being, social support, self efficacy, acceptance of illness, health locus of control and value of health. It employed both a correlational and between groups design. A patient, doctor and nurse estimate of non-adherence was collected and participants were also allocated to one of two groups on the basis of a biological marker of adherence. The qualitative component to the study involved the presentation of two case studies based on a semi-structured interview. Participants were recruited from two inner city hospitals whilst receiving blood transfusions or waiting for a consultation. A total of fifty two subjects were recruited to the quantitative part of the study. The correlational component revealed a weak association between several of the psychosocial variables and non-adherence. In addition, total psychological distress significantly contributed to the prediction of non-adherence as reported by the patients. Lower levels of self efficacy also significantly contributed to the prediction of nonadherence as measured by the doctor. No significant differences were found between the biological groups in relation to any of the psychosocial or demographic variables. In addition, the qualitative component of this study highlighted a number of themes which helped to elucidate the quantitative findings.

Type: Thesis (Doctoral)
Qualification: D.Clin.Psy
Title: Psychosocial factors influencing adherence to iron chelation therapy in patients with thalassaemia
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
Keywords: Psychology; Medication adherence
URI: https://discovery.ucl.ac.uk/id/eprint/10107429
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