UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT

Elfeky, R; Lucchini, G; Lum, S-H; Ottaviano, G; Builes, N; Nademi, Z; Battersby, A; ... Veys, P; + view all (2020) New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT. Blood Advances , 4 (11) pp. 2418-2429. 10.1182/bloodadvances.2019001315. Green open access

[thumbnail of Ottaviano_New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT_VoR.pdf]
Preview
Text
Ottaviano_New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT_VoR.pdf

Download (1MB) | Preview

Abstract

This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5.6%) with no evidence of center variation. Sex, underlying disease, intensity of the conditioning, total body irradiation–based conditioning, the use of calcineurin inhibitors, venoocclusive disease, and viral reactivation did not influence the development of TA-TMA. Donor type: matched sibling donor/matched family donor vs matched unrelated donor vs mismatched unrelated donor/haplo-HSCT, showed a trend toward the development of TA-TMA in 1.8% vs 6.1% vs 8.3%, respectively. Presence of active comorbidity was associated with an increased risk for TA-TMA; 13% vs 3.7% in the absence of comorbidity. The risk of TA-TMA was threefold higher among patients who received >1 transplant. TA-TMA rates were significantly higher among patients with acute graft-versus-host disease (aGVHD) grades III to IV vs aGVHD grade 0 to II. On multivariate analysis, the presence of active comorbidity, >1 transplant, aGVHD grade III to IV were risk factors for TA-TMA (odds ratio [OR]: 5.1, 5.2, and 26.9; respectively), whereas the use of cyclosporine A/tacrolimus-based GVHD prophylaxis was not a risk factor for TA-TMA (OR: 0.3). Active comorbidity, subsequent transplant, and aGVHD grades III to IV were significant risk factors for TA-TMA. TA-TMA might represent a form of a vascular GVHD, and therefore, continuing control of aGVHD is important to prevent worsening of TA-TMA associated with GVHD.

Type: Article
Title: New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT
Open access status: An open access version is available from UCL Discovery
DOI: 10.1182/bloodadvances.2019001315
Publisher version: https://doi.org/10.1182/bloodadvances.2019001315
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: tissue microarray, transplantation, trimethylamine, hematopoietic stem cell transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10107393
Downloads since deposit
54Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item