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Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis

Li, K; Wei, S; Hu, L; Yin, X; Mai, Y; Jiang, C; Peng, X; ... Zhao, B; + view all (2020) Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis. Mediators of Inflammation , 2020 , Article 2058272. 10.1155/2020/2058272. Green open access

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Abstract

Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.

Type: Article
Title: Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2020/2058272
Publisher version: https://doi.org/10.1155/2020/2058272
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10107145
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