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Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach

Iob, E; Schoeler, T; Cecil, CM; Walton, E; McQuillin, A; Pingault, JB; (2020) Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach. Addiction Biology 10.1111/adb.12944. (In press). Green open access

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Abstract

Individuals most often use several rather than one substance among alcohol, cigarettes or cannabis. This widespread co‐occurring use of multiple substances is thought to stem from a common liability that is partly genetic in origin. Genetic risk may indirectly contribute to a common liability to substance use through genetically influenced mental health vulnerabilities and individual traits. To test this possibility, we used polygenic scores indexing mental health and individual traits and examined their association with the common versus specific liabilities to substance use.

Type: Article
Title: Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/adb.12944
Publisher version: https://doi.org/10.1111/adb.12944
Language: English
Additional information: © 2020 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: common liability, mental health, personality, polygenic risk, substance use
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS
URI: https://discovery.ucl.ac.uk/id/eprint/10106738
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