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Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study

Rudnicka, AR; Owen, CG; Welikala, RA; Barman, SA; Whincup, PH; Strachan, DP; Chan, MPY; ... Foster, PJ; + view all (2020) Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study. American Journal of Ophthalmology 10.1016/j.ajo.2020.07.027. (In press). Green open access

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Abstract

Purpose: To examine retinal vasculometry associations with different glaucomas in older British people. Design: Cross-sectional study Methods: 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glaucoma suspect [GS], high tension open-angle glaucoma [HTG], and normal tension glaucoma [NTG]). Automated measures of arteriolar and venular tortuosity, area and width from retinal images were obtained. Main outcome measures: Associations between glaucoma and retinal vasculometry outcomes were analysed using multi-level linear regression, adjusted for age, sex, height, axial length, intra ocular and systemic blood pressure, and within-person clustering, to provide absolute differences in width and area, and percentage differences in vessel tortuosity. Presence or absence of within-person-between-eye differences in retinal vasculometry by diagnoses were examined. Results: 565,593 vessel segments from 5,947 participants (mean age 67.6, SD 7.6 years, 57% women) were included; numbers with HTG, NTG and GS in at least one eye were 87, 82, 439 respectively. Thinner arterioles (-3.2μm; 95%CI -4.4,-1.9μm) and venules (-2.7μm; 95%CI -4.9,-0.5μm) were associated with HTG. Reduced venular area was associated with HTG (-0.2mm2; 95%CI -0.3,-0.1mm2) and NTG (-0.2mm2; 95%CI -0.3,-0.0mm2). Less tortuous retinal arterioles and venules were associated with all glaucomas, but only significantly for GS (-3.9%; 95%CI -7.7,-0.1% and -4.8%; 95%CI -7.4,-2.1% respectively). There was no evidence of within-person-between-eye differences in retinal vasculometry associations by diagnoses. Conclusions: Retinal vessel width associations with glaucoma and novel associations with vessel area and tortuosity, together with no evidence of within-person-between-eye differences in retinal vasculometry, suggest a vascular cause of glaucoma.

Type: Article
Title: Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ajo.2020.07.027
Publisher version: https://doi.org/10.1016/j.ajo.2020.07.027
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Retinal vasculometry, glaucomas, ocular hypertension
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10106516
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