Huang, B-H;
Stamatakis, E;
Chastin, S;
Pearson, N;
Koster, A;
Hamer, M;
(2020)
Cross‐sectional associations of device‐measured sedentary behaviour and physical activity with cardio‐metabolic health in the 1970 British Cohort Study.
Diabetic Medicine
, Article e14392. 10.1111/dme.14392.
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Abstract
Aims: This study aimed to examine the cross‐sectional associations of thigh accelerometry‐assessed sedentary behaviour and moderate‐to‐vigorous physical activity (MVPA) with cardio‐metabolic health markers and prevalent diabetes in a population sample of middle‐aged British adults. / Methods: Participants (n = 4892) from the age‐46‐to‐48 wave of the 1970 British Cohort Study were fitted with a waterproofed activPAL3 micro device. Total/prolonged sedentary time, breaks and MVPA were the main exposures. We dichotomized prolonged sedentary time and MVPA based on the corresponding median, generating four combinations as categorical exposures. Outcomes comprised of diabetes and seven cardio‐metabolic health markers. We used logistic regression and generalized linear models to examine independent/joint associations, conducting a minimally adjusted model including demographics and contextual covariates, and further adjusted for total sedentary time and/or MVPA as applicable. / Results: Each set of 10 sedentary breaks and 1 h of prolonged sedentary time were associated with HbA1c (mmol/mol) [B = −0.18 (−0.33, −0.03) and 2.35 (1.01, 3.69), respectively]. Each set of 10 sedentary breaks and 1 h of MVPA were favourably associated with diabetes [adjusted odds ratio (AOR): 0.80 (0.71, 0.99) and 0.42 (0.26, 0.67), respectively]. Joint analyses showed that only the low MVPA × long sedentary time combination had significantly higher odds for diabetes than the referent high MVPA × short sedentary time combination [AOR: 1.89 (1.17, 3.03)]. / Conclusions: Each set of additional 10 sedentary breaks per day was associated with 20% lower odds for diabetes. A low physical activity level combined with long sedentary time might synergistically deteriorate cardio‐metabolic health.
| Type: | Article |
|---|---|
| Title: | Cross‐sectional associations of device‐measured sedentary behaviour and physical activity with cardio‐metabolic health in the 1970 British Cohort Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/dme.14392 |
| Publisher version: | https://doi.org/10.1111/dme.14392 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106510 |
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