Shakouri, T;
Cha, J-R;
Owji, N;
Haddow, P;
Robinson, TE;
Patel, KD;
García-Gareta, E;
... Knowles, JC; + view all
(2020)
Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants.
Biomedical Materials
10.1088/1748-605X/aba6d2.
(In press).
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Abstract
Three-dimensional (3D) printing enhances the production of on-demand fabrication of patient-specific devices as well as anatomically fitting implants with high complexity in a cost-effective manner. Additive systems that employ vat photopolymerisation such as stereolithography (SLA) and digital light projection (DLP) are used widely in the field of biomedical science and engineering. However, additive manufacturing methods can be limited by the types of materials that can be used. In this study, we present an isosorbide-based formulation for a polymer resin yielding a range of elastic moduli between 1.73 GN/mm2 dependent on the photoinitiator system used as well as the amount of calcium phosphate filler added. The monomer was prepared and enhanced for 3D-printing using an SLA technique that delivered stable and optimized 3D-printed models. The resin discussed could potentially be used following major surgery for the correction of congenital defects, the removal of oral tumours and the reconstruction of the head and neck region. The surgeon is usually limited with devices available to restore both function and appearance and with the ever-increasing demand for low-priced and efficient facial implants, there is an urgent need to advance new manufacturing approaches and implants with a higher osseointegration performance.
| Type: | Article |
|---|---|
| Title: | Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1748-605X/aba6d2 |
| Publisher version: | https://doi.org/10.1088/1748-605X/aba6d2 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 3.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
| Keywords: | 3D Printing, Biomaterials, Bone tissue engineering, Polymer synthesis, Stereolithography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106500 |
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