Agbuduwe, C;
Basu, S;
(2020)
Hematolological Manifestations of COVID-19: From Cytopenia to Coagulopathy.
European Journal of Haematology
10.1111/ejh.13491.
(In press).
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Abstract
Emerging data from the management of patients with coronavirus disease 2019 (COVID‐19) suggests multi‐systemic involvement, including the hemopoietic system. The haematological manifestations of COVID‐19 include blood count anomalies notably lymphopenia and neutrophilia which are of prognostic significance. Hyperferritinemia and elevated lactate dehydrogenase have also been associated with increased mortality. Furthermore, there is considerable evidence of a distinct coagulopathy associated with COVID‐19 characterised by elevated D‐dimers and an increased risk of thrombotic events. This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various haematological manifestations of COVID‐19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic.
| Type: | Article |
|---|---|
| Title: | Hematolological Manifestations of COVID-19: From Cytopenia to Coagulopathy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ejh.13491 |
| Publisher version: | https://doi.org/10.1111/ejh.13491 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | blood count, coagulopathy, COVID-19, cytokine storm, D-dimer, lymphopenia, SARS-CoV-2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106423 |
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