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Recent advancements in the understanding of tetraspanin functions

Florin, L; de Winde, CM; (2020) Recent advancements in the understanding of tetraspanin functions. Medical Microbiology and Immunology , 209 pp. 393-395. 10.1007/s00430-020-00687-x. Green open access

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Abstract

The spatiotemporal coordination of transmembrane proteins plays an important role in an exceptionally wide range of cellular activities, including in all steps of pathogen infection as well as immunological processes. Tetraspanin proteins are the master organizers of membrane proteins, and are therefore involved in physiological and pathophysiological processes, as presented in this special issue “Tetraspanins in Infection and Immunity”. These transmembrane proteins span the membrane four times and form extended subdomains by means of their strong tendency to associate laterally with one another and with different classes of proteins, such as cell surface receptors, immunoglobulins, adhesion and signalling molecules, and proteases [1]. As such, they anchor specific proteins to one site on the cell membrane forming microclusters that then further organize into larger assemblies, the so-called tetraspanin-enriched microdomains. These microdomains enable membrane dynamics, like endocytosis, recycling, exocytosis, cell motility, fusion and signalling. The role of tetraspanins in cell fusion, for example, is described in mammalian reproductive processes and development [2].

Type: Article
Title: Recent advancements in the understanding of tetraspanin functions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00430-020-00687-x
Publisher version: https://doi.org/10.1007/s00430-020-00687-x
Language: English
Additional information: © 2020 Springer Nature Switzerland AG. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10106395
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