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COVID-19 as a Potential Target for Cryobiology and Cryomedicine

Goltsev, AM; Fuller, BJ; Bondarovych, MO; Babenko, NM; Gaevska, YO; Buriak, IA; Dubrava, TG; ... Ostankov, MV; + view all (2020) COVID-19 as a Potential Target for Cryobiology and Cryomedicine. Problems of Cryobiology and Cryomedicine , 30 (2) pp. 107-131. 10.15407/cryo30.02.107. Green open access

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Abstract

The review presents data on immune pathogenesis of COVID-19 and approaches to its prevention and treatment. The low effectiveness of antiviral drugs is caused by the ability of SARS-CoV2 virus to change its own structure and functions. Existing treatment strategies of COVID-19 are focused on applying the direct antiviral therapies, modulation of innate immune response, "cytokine storm" suppression and use of convalescent plasma. Deregulated interaction between innate and adaptive immune systems determines the start of autoimmune process in the virus carrier body, that requires the use of alternative ways to prevent such diseases using cryobiological technologies. The results of studying the immune biological activity of cryopreserved human cord blood leukoconcentrate (cHCBL) and its components by preventive intranasal administration have been presented. The effectiveness of cHCBL is related to the possible reprogramming of the genes responsible for the implementation of the body's immune responses and induction of the "trained" immunity. Such a modification of the immune system state can be the most promising in protecting the body against viruses, in particular COVID-19.

Type: Article
Title: COVID-19 as a Potential Target for Cryobiology and Cryomedicine
Open access status: An open access version is available from UCL Discovery
DOI: 10.15407/cryo30.02.107
Publisher version: https://doi.org/10.15407/cryo30.02.107
Language: English
Additional information: © 2020 A.N. Goltsev, et al. Published by the Institute for Problems of Cryobiology and Cryomedicine This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).
Keywords: SARS-CoV-2, COVID-19, immune system, cryopreserved human cord blood leukoconcentrate, antiviral protection
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10106388
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