Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease

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Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease

Majumdar, A; Tsochatzis, EA; (2020) Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease. Metabolism , 111 (S) , Article 154291. 10.1016/j.metabol.2020.154291. Green open access

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Abstract

The rising tide of non-alcoholic fatty liver disease (NAFLD) associated with the obesity epidemic is a major international health concern. NAFLD is the leading global cause of liver disease with an estimated prevalence of 25% and is the fastest growing indication for liver transplantation (LT). The presence and severity of liver fibrosis is the only histologic predictor of clinical outcomes in this group. NAFLD poses several challenges in the peri-transplant setting including the management of multiple metabolic co-morbidities, post-transplant obesity and cardiovascular risk. However, post-LT outcomes in well-selected NAFLD patients appear similar to non-NAFLD indications, including in the setting of hepatocellular carcinoma (HCC). The rising prevalence of NAFLD may impact potential liver graft donors, which may in-turn adversely affect post-LT outcomes. This review outlines the current epidemiology, natural history and outcomes of NAFLD with a focus on pre- and post-liver transplant settings.

Type:	Article
Title:	Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.metabol.2020.154291
Publisher version:	https://doi.org/10.1016/j.metabol.2020.154291
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI:	https://discovery.ucl.ac.uk/id/eprint/10106368