UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Active surveillance for low-risk prostate cancer – in pursuit of a standardized protocol

Sosnowski, R; Kamecki, H; Daneshmand, S; Rudzinski, JK; Bjurlin, MA; Giganti, F; Roobol, MJ; (2020) Active surveillance for low-risk prostate cancer – in pursuit of a standardized protocol. Central European Journal of Urology , 73 (2) pp. 123-126. 10.5173/ceju.2020.0167. Green open access

[thumbnail of Giganti_Active surveillance for low-risk prostate cancer In pursuit of a standard protocol v8.pdf]
Preview
Text
Giganti_Active surveillance for low-risk prostate cancer In pursuit of a standard protocol v8.pdf - Accepted Version

Download (630kB) | Preview

Abstract

Introduction: Active surveillance (AS) is a management option recommended by most guidelines for low risk clinically-localized prostate cancer (LR-CLPC). Data shows that AS is being increasingly adopted into clinical practice worldwide. Our aim was to review the up-to date guidelines and observational studies in regards to AS in LR-CLRPC to gain insight into principles of contemporary clinical practice. Material and methods: Several guidelines on the management of low-risk prostate cancer were reviewed for evidence-based recommendations regarding the protocol of AS. We reviewed the available literature for most recent studies on AS in LR-CLPC. Results: No uniform protocol of AS in LR-CLPC has been recommended up to date and available guidelines significantly differ in terms of protocol schedules and the role of particular tools in monitoring for disease progression. Nevertheless, recent studies on AS in LR-CLPC, in which various protocols were adopted, have demonstrated promising outcomes in regards to cancer-specific survival (99–100% at 5 years, 98.1–99.9% at 10 years, and 94.3–96% at 15 years), with high rates of men remaining within the protocols (23–39% at 10 years). Conclusions: This article is a call for focusing further research on development and recommending a precise and standardized, evidence-based protocol for AS in LR-CLPC.

Type: Article
Title: Active surveillance for low-risk prostate cancer – in pursuit of a standardized protocol
Open access status: An open access version is available from UCL Discovery
DOI: 10.5173/ceju.2020.0167
Publisher version: https://doi.org/10.5173/ceju.2020.0167
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: prostate cancer, active surveillance, protocol, guidelines
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10106190
Downloads since deposit
60Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item