UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The anatomo-clinical picture of the pathological embodiment over someone else's body part after stroke

Pia, L; Fossataro, C; Burin, D; Bruno, V; Spinazzola, L; Gindri, P; Fotopoulou, K; ... Garbarini, F; + view all (2020) The anatomo-clinical picture of the pathological embodiment over someone else's body part after stroke. Cortex , 130 pp. 203-219. 10.1016/j.cortex.2020.05.002. (In press).

[img] Text
Fotopoulou_Text_REV2 NOTRACK_update.pdf - Accepted version
Access restricted to UCL open access staff until 20 May 2021.

Download (669kB)

Abstract

Recently, a monothematic delusion of body ownership due to brain damage (i.e., the embodiment of someone else's body part within the patient's sensorimotor system) has been extensively investigated. Here we aimed at defining in-depth the clinical features and the neural correlates of the delusion. Ninety-six stroke patients in a sub-acute or chronic phase of the illness were assessed with a full ad-hoc protocol to evaluate the embodiment of an alien arm under different conditions. A sub-group of seventy-five hemiplegic patients was also evaluated for the embodiment of the movements of the alien arm. Fifty-five patients were studied to identify the neural bases of the delusion by means of voxel-based lesion-symptom mapping approach. Our results show that, in forty percent of the whole sample, simply viewing the alien arm triggered the delusion, but only if it was a real human arm and that was seen from a 1st person perspective in an anatomically-correct position. In the hemiplegic sub-group, the presence of the embodiment of the alien arm was always accompanied by the embodiment of its passive and active movements. Furthermore, the delusion was significantly associated to primary proprioceptive deficits and to damages of the corona radiata and the superior longitudinal fasciculus. To conclude, we show that the pathological embodiment of an alien arm is well-characterized by recurrent and specific features and might be explained as a disconnection deficit, mainly involving white matter tracts. The proposed exhaustive protocol can be successfully employed to assess stroke-induced disorders of body awareness, unveiling even their more undetectable or covert clinical forms.

Type: Article
Title: The anatomo-clinical picture of the pathological embodiment over someone else's body part after stroke
Location: Italy
DOI: 10.1016/j.cortex.2020.05.002
Publisher version: https://doi.org/10.1016/j.cortex.2020.05.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bodily self, Body ownership, Brain-damaged patients, Delusional body ownership, Sense of agency
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10106186
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item