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Living alone and risk of dementia: A systematic review and meta-analysis

Desai, R; John, A; Stott, J; Charlesworth, G; (2020) Living alone and risk of dementia: A systematic review and meta-analysis. Ageing Research Reviews , 62 , Article 101122. 10.1016/j.arr.2020.101122.

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Abstract

AIMS: To systematically review longitudinal studies on living alone and incident dementia, to pool the results in a meta-analysis and calculate the population risk. METHODS: Embase, Medline and PsycInfo were searched from inception to August 2019 for longitudinal cohort studies of people living alone and risk of dementia. Relative risks (RR) were extracted and effect sizes pooled, with a sensitivity analysis for risk of bias (QUIPS quality rating tool). Population Attributable Fraction (PAF) was calculated, with prevalence of living alone calculated from UK Census data. RESULTS: Twelve studies were identified for inclusion, nine of which had low risk of bias. The pooled effect size indicated an elevated risk of incident dementia when living alone (all studies RR = 1.30; 95% CI: 1.15-1.46; low risk of bias studies (RR = 1.31; 95% CI: 1.13-1.51). The PAF for living alone was 8.9%. CONCLUSIONS: Social isolation is a more important risk factor for dementia than previously identified, with living alone associated with greater population risk than physical inactivity, hypertension, diabetes and obesity.

Type: Article
Title: Living alone and risk of dementia: A systematic review and meta-analysis
Location: England
DOI: 10.1016/j.arr.2020.101122
Publisher version: https://doi.org/10.1016/j.arr.2020.101122
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: dementia, social isolation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10106180
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