Xiong, X;
Chua, GT;
Chi, S;
Kwan, MYW;
Wong, WHS;
Zhou, A;
Shek, CC;
... Lp, P; + view all
(2020)
Haematological and immunological data of Chinese children infected with coronavirus disease 2019.
Data Brief
, 31
, Article 105953. 10.1016/j.dib.2020.105953.
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Abstract
Haematological and immunological data of children with COVID-19 infection is lacking. Between 21st January and 20th March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children’s Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. Their haematological and immunological profiles, including complete blood counts, lymphocyte subsets (T, B and NK cell counts), immunoglobulin (Ig) profiles (IgG, IgA and IgM) and cytokine profiles were analysed and compared between the symptomatic and asymptomatic groups. The median values and the interquartile ranges were calculated. Comparison was made using the Mann–Whitney U test. Children with symptomatic COVID19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels. The obtained data will be utilized for further studies in comparing children and adults with COVID-19 infections in other parts of the world and with different severity .
| Type: | Article |
|---|---|
| Title: | Haematological and immunological data of Chinese children infected with coronavirus disease 2019 |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.dib.2020.105953 |
| Publisher version: | https://doi.org/10.1016/j.dib.2020.105953 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | COVID-19, Children, Chinese, Cytokines, Immunoglobulin, Lymphocyte subsets |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106177 |
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