UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Dopamine boosts intention and action awareness in Parkinson's disease

Di Costa, S; Barow, E; Hidding, U; Mainka, T; Poetter-Nerger, M; Buhmann, C; Moll, CKE; ... Ganos, C; + view all (2020) Dopamine boosts intention and action awareness in Parkinson's disease. Experimental Brain Research 10.1007/s00221-020-05847-2. (In press). Green open access

[img]
Preview
Text
Costa2020_Article_DopamineBoostsIntentionAndActi.pdf - Published version

Download (477kB) | Preview

Abstract

Dopaminergic deficiency in Parkinson’s disease (PD) has been associated with underactivation of the supplementary motor area and a reduction of voluntary actions. In these patients, awareness of intention to act has been shown to be delayed. However, delayed awareness of intention to act has also been shown in patients with hyperdopaminergic states and an excess of unwilled movements, as in Tourette’s, and in patients with functional movement disorders. Hence, the role of dopamine in the awareness of intention and action remains unclear. 36 PD patients were tested ON and OFF dopaminergic medication and compared with 35 healthy age-matched controls. In addition, 17 PD patients with subthalamic deep brain stimulation (DBS) were tested ON medication and ON and OFF stimulation. Participants judged either the moment a self-generated action was performed, or the moment the urge to perform the action was felt, using the “Libet method”. Temporal judgments of intention and action awareness were comparable between unmedicated PD patients and controls. Dopaminergic medication boosted anticipatory awareness of both intentions and actions in PD patients, relative to an unmedicated condition. The difference between ON/OFF DBS was not statistically reliable. Functional improvement of motor ability in PD through dopaminergic supplementation leads to earlier awareness of both intention, and of voluntary action.

Type: Article
Title: Dopamine boosts intention and action awareness in Parkinson's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00221-020-05847-2
Publisher version: https://doi.org/10.1007/s00221-020-05847-2
Language: English
Additional information: © 2020 Springer Nature Switzerland AG. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Parkinson's disease, Intention awareness, Action awareness, Dopamine, Libet
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10105461
Downloads since deposit
16Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item