Wang, Y;
Sinha, N;
Schroeder, GM;
Ramaraju, S;
McEvoy, AW;
Miserocchi, A;
De Tisi, J;
... Taylor, PN; + view all
(2020)
Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time.
Epilepsia
10.1111/epi.16580.
(In press).
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Abstract
Objective: Predicting postoperative seizure freedom using functional correlation networks derived from interictal intracranial electroencephalography (EEG) has shown some success. However, there are important challenges to consider: (1) electrodes physically closer to each other naturally tend to be more correlated, causing a spatial bias; (2) implantation location and number of electrodes differ between patients, making cross‐subject comparisons difficult; and (3) functional correlation networks can vary over time but are currently assumed to be static. / Methods: In this study, we address these three challenges using intracranial EEG data from 55 patients with intractable focal epilepsy. Patients additionally underwent preoperative magnetic resonance imaging (MRI), intraoperative computed tomography, and postoperative MRI, allowing accurate localization of electrodes and delineation of the removed tissue. / Results: We show that normalizing for spatial proximity between nearby electrodes improves prediction of postsurgery seizure outcomes. Moreover, patients with more extensive electrode coverage were more likely to have their outcome predicted correctly (area under the receiver operating characteristic curve > 0.9, P « 0.05) but not necessarily more likely to have a better outcome. Finally, our predictions are robust regardless of the time segment analyzed. / Significance: Future studies should account for the spatial proximity of electrodes in functional network construction to improve prediction of postsurgical seizure outcomes. Greater coverage of both removed and spared tissue allows for predictions with higher accuracy.
| Type: | Article |
|---|---|
| Title: | Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/epi.16580 |
| Publisher version: | https://doi.org/10.1111/epi.16580 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | cortical localization, EEG, epilepsy surgery, epileptogenic zone, intracranial electrodes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10105391 |
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