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Enhancing distraction osteogenesis with CFR-PEEK bone pins and a 3D printed transfer device to permit artefact-free three-dimensional magnetic resonance imaging

Moazen, M; Eley, KA; Delso, G; Javidan, M; Kaggie, J; Kalaskar, D; Knowles, JC; ... Watt-Smith, SR; + view all (2020) Enhancing distraction osteogenesis with CFR-PEEK bone pins and a 3D printed transfer device to permit artefact-free three-dimensional magnetic resonance imaging. Journal of Craniofacial Surgery 10.1097/SCS.0000000000006908. (In press).

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Eley et al 2020 Hemifacial Distraction Paper submitted version.pdf - Accepted version
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Abstract

Objectives: To: (1) design an artefact-free 3D-printed MR-safe temporary transfer device, (2) engineer bone-pins from carbon fiber reinforced polyether ether ketone (CFR-PEEK), (3) evaluate the imaging artefacts of CFR-PEEK, and (4) confirm the osteointegration potential of CFR-PEEK, thus enhancing 3D-planning of bony advancements in hemifacial microsomia using sequential magnetic resonance imaging (MRI). Study Design: Engineered CRF-PEEK bone pins and a 3D printed ex-fix device were implanted into a sheep head and imaged with MRI and computed tomography . The osseointegration and bony compatibility potential of CFR-PEEK was assessed with scanning electron microscopy images of MC3T3 preosteoblast cells on the surface of the material. Results: The CFR-PEEK pins resulted in a signal void equivalent to the dimension of the pin, with no adjacent areas of MR-signal loss or computed tomography artefact. MCT3 cells adhered and proliferated on the surface of the discs by forming a monolayer of cells, confirming compatibility and osseointegration potential. Conclusion: A 3D printed transfer device could be utilized temporarily during MRI to permit artefact-free 3D planning. CFR-PEEK pins eliminate imaging artefact permitting sequential MRI examination. In combination, this has the potential to enhance distraction osteogenesis, by permitting accurate three-dimensional planning without ionizing radiation.

Type: Article
Title: Enhancing distraction osteogenesis with CFR-PEEK bone pins and a 3D printed transfer device to permit artefact-free three-dimensional magnetic resonance imaging
DOI: 10.1097/SCS.0000000000006908
Publisher version: https://doi.org/10.1097/SCS.0000000000006908
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10104417
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