Mills, Catherine Ellen;
(2000)
Rhodium catalysed tandem hydrosilylation cyclisation reactions.
Masters thesis (M.Phil), UCL (University College London).
Text
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Abstract
Work has begun on defining the scope of a novel tandem hydrosilylation cyclisation reaction as a general method for the synthesis of substituted carbocycles. Part I: Substituted cyclopentanols are accessible from 4-pentenals in moderate yield and cis selectivity. When R=CO2Me, a reversal in selectivity can be effected through the choice of the catalytic system. Part II: This methodology is compatible with 4, 5-substitution of the parent substrate, generating functionalised cyclopentanols in moderate selectivity and good yield. Part III; Tandem hydrosilylation cyclisation chemistry is applicable to the synthesis of substituted cyclohexanols. Conclusion: This novel chemistry provides a simple entry from lactols to highly substituted cyclopentanols and cyclohexanols in moderate yield and selectivity.
Type: | Thesis (Masters) |
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Qualification: | M.Phil |
Title: | Rhodium catalysed tandem hydrosilylation cyclisation reactions |
Open access status: | An open access version is available from UCL Discovery |
Language: | English |
Additional information: | Thesis digitised by ProQuest. |
Keywords: | Pure sciences; Carbocycles |
URI: | https://discovery.ucl.ac.uk/id/eprint/10104390 |
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