Nibali, L;
Sousa, V;
Davrandi, M;
Spratt, D;
Alyahya, Q;
Dopico, J;
Donos, N;
(2020)
Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis.
Journal of Clinical Periodontology
10.1111/jcpe.13330.
(In press).
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Abstract
AIMS: The primary aim of this investigation was to analyse the periodontal microbiome in patients with aggressive periodontitis (AgP) following treatment. METHODS: 66 AgP patients were recalled on average 7 years after completion of active periodontal treatment and had subgingival plaque samples collected and processed for 16S rRNA gene sequencing analyses. RESULTS: 52 out of 66 participants showed persistent periodontal disease, while 13 participants were considered as 'successfully-treated AgP' (no probing pocket depths >4mm) and 1 was fully edentulous. Genera associated with persistent generalised disease included Actinomyces, Alloprevotella, Capnocytophaga, Filifactor, Fretibacterium, Fusobacterium, Leptotrichia, Mogibacterium, Saccharibacteria [G-1], Selenomonas and Treponema. 'Successfully treated' patients harboured higher proportions of Haemophilus, Rothia, and Lautropia and of Corynebacterium, Streptococcus, and Peptidiphaga genera. Overall, patients with persistent Generalised AgP (GAgP) revealed higher alpha diversity compared to persistent Localised AgP (LAgP) and stable patients (p<0.001). Beta diversity analyses revealed significant differences only between stable and persistent GAgP groups (p=0.004). CONCLUSION: Patients with persistent AgP showed a more dysbiotic subgingival biofilm than those who have been successfully treated. It remains to be established whether such differences were predisposing to disease activity or were a result of a dysbiotic change associated with disease recurrence in the presence of sub-standard supportive periodontal therapy or other patient-related factors.
| Type: | Article |
|---|---|
| Title: | Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpe.13330 |
| Publisher version: | https://doi.org/10.1111/jcpe.13330 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. For more information see: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Aggressive periodontitis, Dysbiosis, Microbiome, Supportive Periodontal Therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10104129 |
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