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Personalized approaches for the management of glaucoma

Balendra, SI; Zollet, P; Cisa Asinari Di Gresy E Casasca, G; Cordeiro, MF; (2020) Personalized approaches for the management of glaucoma. Expert Review of Precision Medicine and Drug Development , 5 (3) pp. 145-164. 10.1080/23808993.2020.1756770. Green open access

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Abstract

Introduction: Personalized medicine is the future goal across all specialties. Accurate prediction of optimal treatment beneficial and adverse effects could transform patient management. This is of particular importance in chronic conditions, where a ‘trial and error’ approach over months and years can contribute to significant morbidity. Glaucoma is a chronic irreversible progressive optic neuropathy, a leading cause of blindness worldwide. An ideal personalized approach in glaucoma clinic would be to answer the inevitable question in a patient’s first visit: ‘Which treatment option will work best for me so that I won’t go blind?’ / Areas covered: This review will give an overview of the knowledge we have acquired to achieve this goal, particularly discussing using patient’s individual risk factors, their genetic profile, and different treatment modalities, including therapy compliance, to personalize care. / Expert opinion: Pharmacogenomics and genetic profiling are the most tangible ways in which glaucoma management can be personalized. Future challenges will include developing realistic animal models to reflect the underlying genetic patterns in glaucoma to investigate their interaction with different treatments.

Type: Article
Title: Personalized approaches for the management of glaucoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23808993.2020.1756770
Publisher version: https://doi.org/10.1080/23808993.2020.1756770
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: pharamacogenetics, pharmacogenomics, personalization
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10103943
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