UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Prospective Association Among Diabetes Diagnosis, HbA_{lc}, Glycemia, and Frailty Trajectories in an Elderly Population

Aguayo, GA; Hulman, A; Vaillant, MT; Donneau, A-F; Schritz, A; Stranges, S; Malisoux, L; ... Witte, DR; + view all (2019) Prospective Association Among Diabetes Diagnosis, HbA_{lc}, Glycemia, and Frailty Trajectories in an Elderly Population. Diabetes Care , 42 (10) pp. 1903-1911. 10.2337/dc19-0497. Green open access

[thumbnail of Sabia_Prospective Association Among Diabetes Diagnosis, HbA(1c), Glycemia, and Frailty Trajectories in an Elderly Population_AAM.pdf]
Preview
Text
Sabia_Prospective Association Among Diabetes Diagnosis, HbA(1c), Glycemia, and Frailty Trajectories in an Elderly Population_AAM.pdf - Accepted Version

Download (404kB) | Preview

Abstract

OBJECTIVE: Frailty is a dynamic state of vulnerability in the elderly. We examined whether individuals with overt diabetes or higher levels of HbA_{1c} or fasting plasma glucose (FG) experience different frailty trajectories with aging. RESEARCH DESING AND METHODS: Diabetes, HbA_{1c}, and FG were assessed at baseline, and frailty status was evaluated with a 36-item frailty index every 2 years during a 10-year follow-up among participants from the English Longitudinal Study of Ageing (ELSA). Mixed-effects models with age as time scale were used to assess whether age trajectories of frailty differed as a function of diabetes, HbA_{1c}, and FG. RESULTS: mong 5,377 participants (median age [interquartile range] 70 [65, 77] years, 45% men), 35% were frail at baseline. In a model adjusted for sex, participants with baseline diabetes had an increased frailty index over aging compared with those without diabetes. Similar findings were observed with higher levels of HbA_{1c}, while FG was not associated with frailty. In a model additionally adjusted for income, social class, smoking, alcohol, and hemoglobin, only diabetes was associated with an increased frailty index. Among nonfrail participants at baseline, both diabetes and HbA_{1c} level were associated with a higher increased frailty index over time. CONCLUSIONS: People with diabetes or higher HbA_{1c} levels at baseline had a higher frailty level throughout later life. Nonfrail participants with diabetes or higher HbA_{1c} also experienced more rapid deterioration of frailty level with aging. This observation could reflect a role of diabetes complications in frailty trajectories or earlier shared determinants that contribute to diabetes and frailty risk in later life.

Type: Article
Title: Prospective Association Among Diabetes Diagnosis, HbA_{lc}, Glycemia, and Frailty Trajectories in an Elderly Population
Open access status: An open access version is available from UCL Discovery
DOI: 10.2337/dc19-0497
Publisher version: https://doi.org/10.2337/dc19-0497
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10103765
Downloads since deposit
72Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item