Aguayo, GA;
Hulman, A;
Vaillant, MT;
Donneau, A-F;
Schritz, A;
Stranges, S;
Malisoux, L;
... Witte, DR; + view all
(2019)
Prospective Association Among Diabetes Diagnosis, HbA_{lc}, Glycemia, and Frailty Trajectories in an Elderly Population.
Diabetes Care
, 42
(10)
pp. 1903-1911.
10.2337/dc19-0497.
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Abstract
OBJECTIVE: Frailty is a dynamic state of vulnerability in the elderly. We examined whether individuals with overt diabetes or higher levels of HbA_{1c} or fasting plasma glucose (FG) experience different frailty trajectories with aging. RESEARCH DESING AND METHODS: Diabetes, HbA_{1c}, and FG were assessed at baseline, and frailty status was evaluated with a 36-item frailty index every 2 years during a 10-year follow-up among participants from the English Longitudinal Study of Ageing (ELSA). Mixed-effects models with age as time scale were used to assess whether age trajectories of frailty differed as a function of diabetes, HbA_{1c}, and FG. RESULTS: mong 5,377 participants (median age [interquartile range] 70 [65, 77] years, 45% men), 35% were frail at baseline. In a model adjusted for sex, participants with baseline diabetes had an increased frailty index over aging compared with those without diabetes. Similar findings were observed with higher levels of HbA_{1c}, while FG was not associated with frailty. In a model additionally adjusted for income, social class, smoking, alcohol, and hemoglobin, only diabetes was associated with an increased frailty index. Among nonfrail participants at baseline, both diabetes and HbA_{1c} level were associated with a higher increased frailty index over time. CONCLUSIONS: People with diabetes or higher HbA_{1c} levels at baseline had a higher frailty level throughout later life. Nonfrail participants with diabetes or higher HbA_{1c} also experienced more rapid deterioration of frailty level with aging. This observation could reflect a role of diabetes complications in frailty trajectories or earlier shared determinants that contribute to diabetes and frailty risk in later life.
| Type: | Article |
|---|---|
| Title: | Prospective Association Among Diabetes Diagnosis, HbA_{lc}, Glycemia, and Frailty Trajectories in an Elderly Population |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2337/dc19-0497 |
| Publisher version: | https://doi.org/10.2337/dc19-0497 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103765 |
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