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MRI Measurement of Placental Perfusion and Oxygen Saturation in Early Onset Fetal Growth Restriction

Aughwane, R; Mufti, N; Flouri, D; Maksym, K; Spencer, R; Sokolska, M; Kendall, G; ... Melbourne, A; + view all (2020) MRI Measurement of Placental Perfusion and Oxygen Saturation in Early Onset Fetal Growth Restriction. BJOG: An International Journal of Obstetrics & Gynaecology 10.1111/1471-0528.16387. (In press). Green open access

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Abstract

Objective: We hypothesised that a multi‐compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early‐onset fetal growth restriction (FGR). Design: Case–control study. Setting: London, UK. Population: Women with uncomplicated pregnancies (estimated fetal weight [EFW] >10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, n = 12) or early‐onset FGR (EFW <3rd centile with or without abnormal Doppler ultrasound <32 weeks GA, n = 12) were studied. Methods: All women underwent MRI examination. Using a multi‐compartment MRI technique, we quantified fetal and maternal blood volume and feto‐placental blood oxygenation. Main outcome measures: Disease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan. Results: The FGR group (mean GA 27+5 weeks, range 24+2 to 33+6 weeks) had a significantly lower EFW compared with the control group (mean GA 29+1 weeks; −705 g, 95% CI −353 to −1057 g). MRI‐derived feto‐placental oxygen saturation was higher in controls compared with FGR (75 ± 9.6% versus 56 ± 16.2%, P = 0.02, 95% CI 7.8–30.3%). Feto‐placental oxygen saturation estimation correlated strongly with GA at scan in controls (r = −0.83). Conclusion: Using a novel multimodal MRI protocol we demonstrated reduced feto‐placental blood oxygen saturation in pregnancies complicated by early‐onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age‐dependent changes in oxygen saturation were also present in normal pregnancies. Tweetable abstract: MRI reveals differences in feto‐placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity.

Type: Article
Title: MRI Measurement of Placental Perfusion and Oxygen Saturation in Early Onset Fetal Growth Restriction
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.16387
Publisher version: https://doi.org/10.1111/1471-0528.16387
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10103759
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