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3D culture technologies of cancer stem cells: promising ex vivo tumor models

Zhang, C; Yang, Z; Dong, DL; Jang, TS; Knowles, JC; Kim, HW; Jin, GZ; (2020) 3D culture technologies of cancer stem cells: promising ex vivo tumor models. Journal of Tissue Engineering , 11 pp. 1-17. 10.1177/2041731420933407. Green open access

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Abstract

Cancer stem cells have been shown to be important in tumorigenesis processes, such as tumor growth, metastasis, and recurrence. As such, many three-dimensional models have been developed to establish an ex vivo microenvironment that cancer stem cells experience under in vivo conditions. Cancer stem cells propagating in three-dimensional culture systems show physiologically related signaling pathway profiles, gene expression, cell–matrix and cell–cell interactions, and drug resistance that reflect at least some of the tumor properties seen in vivo. Herein, we discussed the presently available Cancer stem cell three-dimensional culture models that use biomaterials and engineering tools and the biological implications of these models compared to the conventional ones.

Type: Article
Title: 3D culture technologies of cancer stem cells: promising ex vivo tumor models
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731420933407
Publisher version: https://doi.org/10.1177%2F2041731420933407
Language: English
Additional information: © 2020 by SAGE Publications Ltd, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/).
Keywords: 3D culture; tumor model, cancer stem cells, biomaterials, tumor biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10103729
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