Zhang, C;
Yang, Z;
Dong, DL;
Jang, TS;
Knowles, JC;
Kim, HW;
Jin, GZ;
(2020)
3D culture technologies of cancer stem cells: promising ex vivo tumor models.
Journal of Tissue Engineering
, 11
pp. 1-17.
10.1177/2041731420933407.
Preview |
Text
Journal of Tissue Engineering 11 2041731420933407.pdf - Published Version Download (1MB) | Preview |
Abstract
Cancer stem cells have been shown to be important in tumorigenesis processes, such as tumor growth, metastasis, and recurrence. As such, many three-dimensional models have been developed to establish an ex vivo microenvironment that cancer stem cells experience under in vivo conditions. Cancer stem cells propagating in three-dimensional culture systems show physiologically related signaling pathway profiles, gene expression, cell–matrix and cell–cell interactions, and drug resistance that reflect at least some of the tumor properties seen in vivo. Herein, we discussed the presently available Cancer stem cell three-dimensional culture models that use biomaterials and engineering tools and the biological implications of these models compared to the conventional ones.
| Type: | Article |
|---|---|
| Title: | 3D culture technologies of cancer stem cells: promising ex vivo tumor models |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/2041731420933407 |
| Publisher version: | https://doi.org/10.1177%2F2041731420933407 |
| Language: | English |
| Additional information: | © 2020 by SAGE Publications Ltd, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | 3D culture; tumor model, cancer stem cells, biomaterials, tumor biology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103729 |
Archive Staff Only
 |
View Item |
