Jafree, DJ;
Long, DA;
(2020)
Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases.
Journal of the American Society of Nephrology
, 31
(6)
pp. 1178-1190.
10.1681/ASN.2019121320.
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Abstract
The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.
| Type: | Article |
|---|---|
| Title: | Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1681/ASN.2019121320 |
| Publisher version: | http://dx.doi.org/10.1681/ASN.2019121320 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cell signaling, endothelial cells, kidney development, kidney disease, pathophysiology of renal disease and progression, renal cell biology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103526 |
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