Perretta-Tejedor, N;
Jafree, DJ;
Long, DA;
(2020)
Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling.
Cellular Signalling
, 72
, Article 109624. 10.1016/j.cellsig.2020.109624.
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Abstract
Whereas targeting the cyst epithelium and its molecular machinery has been the prevailing clinical strategy for polycystic kidney disease, the endothelium, including blood vasculature and lymphatics, is emerging as an important player in this disorder. In this Review, we provide an overview of the structural and functional alterations to blood vasculature and lymphatic vessels in the polycystic kidney. We also discuss evidence for vascular endothelial growth factor signalling, otherwise critical for endothelial cell development and maintenance, as being a fundamental molecular pathway in polycystic kidney disease and a potential therapeutic target for modulating cyst expansion.
| Type: | Article |
|---|---|
| Title: | Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cellsig.2020.109624 |
| Publisher version: | http://dx.doi.org/10.1016/j.cellsig.2020.109624 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Blood vessel, Endothelium, Epithelium, Kidney, Lymphatics, Vascular endothelial growth factor, |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103521 |
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