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Galectins and their involvement in ocular disease and development

Luis, J; Eastlake, K; Khaw, PT; Limb, GA; (2020) Galectins and their involvement in ocular disease and development. Experimental Eye Research 10.1016/j.exer.2020.108120. (In press).

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Abstract

Galectins are carbohydrate binding proteins with high affinity to ß-galactoside containing glycoconjugates. Understanding of the functions of galectins has grown steadily over the past decade, as a result of substantial advancements in the field of glycobiology. Galectins have been shown to be versatile molecules that participate in a range of important biological systems, including inflammation, neovascularisation and fibrosis. These processes are of particular importance in ocular tissues, where a major theme of recent research has been to divert diseases away from pathways which result in loss of function into pathways of repair and regeneration. This review summarises our current understanding galectins in the context important ocular diseases, followed by an update on current clinical studies and future directions.

Type: Article
Title: Galectins and their involvement in ocular disease and development
Location: England
DOI: 10.1016/j.exer.2020.108120
Publisher version: https://doi.org/10.1016/j.exer.2020.108120
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Galectin, Ophthalmology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10103101
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