McDonald, Elizabeth; (1993) The psychological effects of interferon treatment in patients with hepatitis B. Masters thesis (M.Phil), UCL (University College London).

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Abstract

The study examined psychiatric morbidity in forty-three subjects who were participants in a controlled randomised trial using recombinant alpha 2A interferon to treat chronic hepatitis B infection. Two standardised psychiatric instruments, the General Health Questionnaire and the Clinical Interview Schedule, were used to elicit morbidity in the subjects before treatment with interferon, during treatment and after treatment. The measures showed a rise in psychiatric symptoms among those on interferon treatment compared with matched controls. The symptoms were non-psychotic in nature, the most commonly reported being fatigue, impaired concentration and irritability. The observed increase in psychiatric morbidity remained even when social stresses and life events were controlled for.

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