UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Angiomatoid Fibrous Histiocytoma With ALK Expression in an Unusual Location and Age Group

De Noon, S; Fleming, A; Singh, M; (2020) Angiomatoid Fibrous Histiocytoma With ALK Expression in an Unusual Location and Age Group. American Journal of Dermatopathology , 42 (9) pp. 689-693. 10.1097/DAD.0000000000001649. Green open access

[img]
Preview
Text
AFH final version.pdf - Accepted version

Download (1MB) | Preview

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a relatively rare soft tissue tumor of intermediate malignant potential, occurring most commonly in young adults, with a recognized propensity for local recurrence and occasional metastasis. A case of AFH occurring on the finger of a 60-year-old man is described in which the unusual location and age group for this entity raised the original wrong diagnosis of an aneurysmal and cellular fibrous histiocytoma. Further workup demonstrated an EWSR1-CREB1 translocation, confirming the correct diagnosis of AFH. Strong anaplastic lymphoma kinase (ALK) expression using the antibody clone D5F3 was demonstrated in our case on immunohistochemistry, which is in concordance with recent findings of anaplastic lymphoma kinase positivity with this antibody in the majority of AFHs.

Type: Article
Title: Angiomatoid Fibrous Histiocytoma With ALK Expression in an Unusual Location and Age Group
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/DAD.0000000000001649
Publisher version: https://doi.org/10.1097/DAD.0000000000001649
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10102991
Downloads since deposit
9Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item