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Long-term super-resolution imaging of amyloid structures using transient binding of Thioflavin T

Spehar, K; Ding, T; Sun, Y; Kedia, N; Lu, J; Nahass, GR; Lew, MD; (2019) Long-term super-resolution imaging of amyloid structures using transient binding of Thioflavin T. In: Optical Molecular Probes, Imaging and Drug Delivery - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP). OSA: Tucson, AZ, USA. Green open access

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Abstract

Amyloids are implicated in Alzheimer’s disease but cannot be well resolved by standard light microscopy. We developed a tool to directly image native amyloid structures and dynamics at nanometer resolution over minutes to days.

Type: Proceedings paper
Title: Long-term super-resolution imaging of amyloid structures using transient binding of Thioflavin T
Event: Optical Molecular Probes, Imaging and Drug Delivery 2019
ISBN-13: 9781943580545
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/OMP.2019.OW4D.4
Publisher version: https://doi.org/10.1364/OMP.2019.OW4D.4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10102866
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