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Probing the Mobilome: Discoveries in the Dynamic Microbiome

Carr, VR; Shkoporov, A; Hill, C; Mullany, P; Moyes, DL; (2021) Probing the Mobilome: Discoveries in the Dynamic Microbiome. Trends in Microbiology , 29 (2) pp. 158-170. 10.1016/j.tim.2020.05.003. Green open access

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Abstract

There has been an explosion of metagenomic data representing human, animal, and environmental microbiomes. This provides an unprecedented opportunity for comparative and longitudinal studies of many functional aspects of the microbiome that go beyond taxonomic classification, such as profiling genetic determinants of antimicrobial resistance, interactions with the host, potentially clinically relevant functions, and the role of mobile genetic elements (MGEs). One of the most important but least studied of these aspects are the MGEs, collectively referred to as the 'mobilome'. Here we elaborate on the benefits and limitations of using different metagenomic protocols, discuss the relative merits of various sequencing technologies, and highlight relevant bioinformatics tools and pipelines to predict the presence of MGEs and their microbial hosts.

Type: Article
Title: Probing the Mobilome: Discoveries in the Dynamic Microbiome
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tim.2020.05.003
Publisher version: https://doi.org/10.1016/j.tim.2020.05.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10102826
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