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Flexible Bayesian Modelling for Nonlinear Image Registration

Brudfors, M; Balbastre, Y; Flandin, G; Nachev, P; Ashburner, J; (2020) Flexible Bayesian Modelling for Nonlinear Image Registration. In: Martel, A and Abolmaesumi, P and Stoyanov, D and Mateus, D and ZuluagaM, M and Zhou, SK and Racoceanu, D and Joskowicz, L, (eds.) Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. (pp. pp. 253-263). Springer: Lima, Peru. Green open access

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Abstract

We describe a diffeomorphic registration algorithm that allows groups of images to be accurately aligned to a common space, which we intend to incorporate into the SPM software. The idea is to perform inference in a probabilistic graphical model that accounts for variability in both shape and appearance. The resulting framework is general and entirely unsupervised. The model is evaluated at inter-subject registration of 3D human brain scans. Here, the main modeling assumption is that individual anatomies can be generated by deforming a latent ‘average’ brain. The method is agnostic to imaging modality and can be applied with no prior processing. We evaluate the algorithm using freely available, manually labelled datasets. In this validation we achieve state-of-the-art results, within reasonable runtimes, against previous state-of-the-art widely used, inter-subject registration algorithms. On the unprocessed dataset, the increase in overlap score is over 17%. These results demonstrate the benefits of using informative computational anatomy frameworks for nonlinear registration.

Type: Proceedings paper
Title: Flexible Bayesian Modelling for Nonlinear Image Registration
Event: International Conference on Medical Image Computing and Computer-Assisted Intervention
ISBN-13: 9783030597153
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-030-59716-0_25
Publisher version: https://doi.org/10.1007/978-3-030-59716-0_25
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10102550
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