UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy

Pal, UM; Vaidya, J; Pandya, H; (2020) Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy. IEEE Transactions on Biomedical Circuits and Systems 10.1109/TBCAS.2020.3005971. (In press). Green open access

[thumbnail of Vaidya_Accepted Manuscript.pdf]
Preview
Text
Vaidya_Accepted Manuscript.pdf - Accepted version

Download (1MB) | Preview

Abstract

Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850 nm, 935 nm, and 1060 nm. We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p-values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850 nm, 935 nm, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for non-invasive and non-carcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples.

Type: Article
Title: Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TBCAS.2020.3005971
Publisher version: http://dx.doi.org/10.1109/TBCAS.2020.3005971
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Near-infrared spectroscopy, Breast cancer, Biopsy tissue, Lipids, Collagens, Non-invasive
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10102389
Downloads since deposit
107Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item