Pal, UM;
Vaidya, J;
Pandya, H;
(2020)
Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy.
IEEE Transactions on Biomedical Circuits and Systems
10.1109/TBCAS.2020.3005971.
(In press).
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Abstract
Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850 nm, 935 nm, and 1060 nm. We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p-values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850 nm, 935 nm, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for non-invasive and non-carcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples.
| Type: | Article |
|---|---|
| Title: | Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TBCAS.2020.3005971 |
| Publisher version: | http://dx.doi.org/10.1109/TBCAS.2020.3005971 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Near-infrared spectroscopy, Breast cancer, Biopsy tissue, Lipids, Collagens, Non-invasive |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10102389 |
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