Tapon, Nicolas Alexandre Marie; (1998) Identification of new targets for the Rho and Rac GTPases. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

Rho and Rac are small GTP binding proteins which, as molecular switches, are involved in the co-ordinated regulation of the actin cytoskeleton and gene transcription. Rho controls the formation of actin stress fibres and focal adhesion assembly, while Rac regulates formation of lamellipodia and focal complexes. Both Rho and Rac have also been implicated in regulation of gene transcription through the Serum Response Factor, NFκB, and JNK MAP Kinase pathways. It is thought that Rho and Rac mediate these effects by interacting with a variety of cellular targets, but the molecular details of the signalling pathways involved are still unclear. In this thesis I describe the cloning and characterisation of ROKβ and POSH, two targets of Rho and Rac GTPases. ROKβ is a candidate target for Rho and Rac in controlling the actin cytoskeleton. POSH is a candidate target for Rac in controlling gene transcription through the NFκB and JNK pathways.

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