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Repetitive negative thinking is associated with amyloid, tau, and cognitive decline.

Marchant, NL; Lovland, LR; Jones, R; Pichet Binette, A; Gonneaud, J; Arenaza-Urquijo, EM; Chételat, G; ... PREVENT-AD Research Group; + view all (2020) Repetitive negative thinking is associated with amyloid, tau, and cognitive decline. Alzheimer’s & Dementia 10.1002/alz.12116. (In press). Green open access

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Abstract

INTRODUCTION: The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer's disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety and depression symptoms. METHODS: Two hundred and ninety-two older adults with longitudinal cognitive assessments, including 113 with amyloid-positron emission tomography (PET) and tau-PET scans, from the PREVENT-AD cohort and 68 adults with amyloid-PET scans from the IMAP+ cohort were included. All participants completed RNT, anxiety, and depression questionnaires. RESULTS: RNT was associated with decline in global cognition (P = .02); immediate (P = .03) and delayed memory (P = .04); and global amyloid (PREVENT-AD: P = .01; IMAP+: P = .03) and entorhinal tau (P = .02) deposition. Relationships remained after adjusting for potential confounders. DISCUSSION: RNT was associated with decline in cognitive domains affected early in AD and with neuroimaging AD biomarkers. Future research could investigate whether modifying RNT reduces AD risk.

Type: Article
Title: Repetitive negative thinking is associated with amyloid, tau, and cognitive decline.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/alz.12116
Publisher version: https://doi.org/10.1002/alz.12116
Language: English
Additional information: © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: Alzheimer's disease, amyloid, cognition, depression, repetitive negative thinking, rumination, tau, worry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10101468
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