Nordstrom, BL;
Oguz, M;
Chu, BC;
Ouwens, M;
Arkenau, H-T;
Klein, AB;
(2020)
Effectiveness of durvalumab versus chemotherapy in metastatic urothelial cancer: an observational, indirect comparison.
Journal of Comparative Effectiveness Research
, 9
(3)
pp. 191-199.
10.2217/cer-2019-0163.
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Abstract
Aim: To compare the overall survival of patients with metastatic urothelial carcinoma (mUC) who failed platinum-based chemotherapy and received durvalumab or chemotherapy. / Patients & methods: In an indirect comparison of patients with mUC who failed platinum-based chemotherapy, those who received durvalumab in a single-arm study were matched to patients from the Flatiron oncology electronic medical record database who received chemotherapy (n = 158 for each cohort). Matching was based on propensity scores. Kaplan–Meier methods and Cox regression models were utilized. / Results: Median overall survival was 11.2 months (95% CI: 7.2–16.9) for durvalumab versus 8.2 months (95% CI: 6.7–9.8) for chemotherapy (hazard ratio: 0.63; 95% CI: 0.48–0.84). / Conclusion: As a second-line therapy for mUC, durvalumab was associated with longer overall survival than chemotherapy.
| Type: | Article |
|---|---|
| Title: | Effectiveness of durvalumab versus chemotherapy in metastatic urothelial cancer: an observational, indirect comparison |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/cer-2019-0163 |
| Publisher version: | https://doi.org/10.2217/cer-2019-0163 |
| Language: | English |
| Additional information: | Copyright © 2020 Beth L Nordstrom. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| Keywords: | chemotherapy, durvalumab, indirect treatment comparison, observational, overall survival, urothelial carcinoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10101053 |
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