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Découverte fortuite d’une atteinte hépatique d’amylose à leukocyte chemotactic factor 2 [Incidental finding of leukocyte cell-derived chemotaxin 2 – Associated amyloidosis in a liver]

Gibier, J-B; Gilbertson, JA; Perbet, R; Leriche, W; Truant, S; Leteurtre, E; Gillmore, JD; (2020) Découverte fortuite d’une atteinte hépatique d’amylose à leukocyte chemotactic factor 2 [Incidental finding of leukocyte cell-derived chemotaxin 2 – Associated amyloidosis in a liver]. Annales de Pathologie , 40 (6) pp. 472-477. 10.1016/j.annpat.2020.04.007. Green open access

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Abstract

L’amylose associée à la protéine leukocyte cell-derived chemotaxin 2 (ALECT2) a été identifiée aux États-Unis en 2007. Cette forme systémique d’amylose est associée à certaines ethnies et a principalement été rapportée aux États-Unis et au Moyen-Orient. L’ALECT2 est le plus souvent diagnostiquée sur une ponction biopsie rénale au cours du bilan d’une insuffisance rénale chronique lentement progressive mais peut également être découverte fortuitement sur un prélèvement hépatique. Nous rapportons ici le cas d’un patient, d’origine syrienne, ayant bénéficié d’une hépatectomie partielle pour la prise en charge de métastases multiples d’un adénocarcinome colorectal. L’examen microscopique de la pièce d’exérèse a permis la mise en évidence d’abondants dépôts amyloïdes, dont le typage de routine n’était pas en faveur d’une forme usuelle d’amylose. Certaines caractéristiques morphologiques des dépôts étaient évocatrices d’une ALECT2. Ce diagnostic a été confirmé par immunohistochimie et par étude en spectrométrie de masse. / Leukocyte cell-derived chemotaxin 2-associated amyloidosis (ALECT2) is a recently described of amyloidosis described in the United States in 2007. It is a systemic disease that is predominantly associated with some ethnics groups. ALECT2 is usually diagnosed on a kidney biopsy performed in the context of slowly progressive chronic renal disease but can also be found incidentally on a liver sample. We report the case of a Syrian patient who benefited from a partial hepatectomy for the treatment of multiple metastasis of a colorectal adenocarcinoma. Microscopic analysis of the surgical specimen revealed numerous amyloid deposits that did not match any of the usual forms of liver amyloidosis after immunohistochemistry typing. Some morphologic features of the deposits were highly suggestive of ALECT2. Complementary immunohistochemical study and mass spectrometry confirmed the diagnosis.

Type: Article
Title: Découverte fortuite d’une atteinte hépatique d’amylose à leukocyte chemotactic factor 2 [Incidental finding of leukocyte cell-derived chemotaxin 2 – Associated amyloidosis in a liver]
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.annpat.2020.04.007
Publisher version: https://doi.org/10.1016/j.annpat.2020.04.007
Language: French
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Amyloidosis, Amylose, Foie, LECT2, Liver, Mass spectrometry, Spectrométrie de masse
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10100835
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