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Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity

Chin, MHW; Gentleman, E; Coppens, MO; Day, RM; (2020) Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity. Trends in Biotechnology , 38 (10) pp. 1054-1065. 10.1016/j.tibtech.2020.05.003. Green open access

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Abstract

The meteoric rise of cancer immunotherapy in the past decade has led to promising treatments for a number of hard-to-treat malignancies. In particular, adoptive T cell therapy has recently reached a major milestone with two products approved by the US FDA. However, the inherent complexity of cell-based immunotherapies means that their manufacturing time, cost, and controllability limit their effectiveness and geographic reach. One way to address these issues may lie in complementing the dominant, reductionistic mentality in modern medicine with complex systems thinking. In this opinion article, we identify key concepts from complexity theory to address manufacturing challenges in cell-based immunotherapies and raise the possibility of a unifying framework upon which future bioprocessing strategies may be designed.

Type: Article
Title: Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibtech.2020.05.003
Publisher version: https://doi.org/10.1016/j.tibtech.2020.05.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: bioengineering, complex systems, holism, immunotherapy, process intensification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10100686
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