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Polymersomes Eradicating Intracellular Bacteria

Fenaroli, F; Robertson, JD; Scarpa, E; Gouveia, VM; Di Guglielmo, C; De Pace, C; Elks, PM; ... Rizzello, L; + view all (2020) Polymersomes Eradicating Intracellular Bacteria. ACS Nano , 14 (7) pp. 8287-8298. 10.1021/acsnano.0c01870. Green open access

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Abstract

Mononuclear phagocytes such as monocytes, tissue-specific macrophages and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favouring chronic and/or disseminated infection. One of the most infamous is the bacteria that cause tuberculosis (TB), which is the most pandemic and one of the deadliest diseases with one third of the world's population infected, and an average of 1.8 million deaths/year worldwide. Here we demonstrate the effective targeting and intracellular delivery of antibiotics to infected macrophages both in vitro and in vivo, using pH sensitive nanoscopic polymersomes made of PMPC-PDPA block copolymer. Polymersomes showed the ability to significantly enhance the efficacy of the antibiotics killing Mycobacterium bovis, Mycobacterium tuberculosis and another established intracellular pathogen the Staphylococcus aureus. Moreover, they demonstrated to easily access TB-like granuloma tissues - one of the harshest environments to penetrate - in zebrafish models. We thus successfully exploited this targeting for the effective eradication of several intracellular bacteria, including the M. tuberculosis - the etiological agent of human TB.

Type: Article
Title: Polymersomes Eradicating Intracellular Bacteria
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsnano.0c01870
Publisher version: https://doi.org/10.1021/acsnano.0c01870
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Immunology, Infectious diseases, Antimicrobial agents, Bacteria, Zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10100641
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