Triantos, Dimitris; (1998) Oral and dental aspects of HIV disease. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

This thesis has examined various oral and dental aspects of HIV disease. A non -isotopic single-strand conformation polymorphism procedure was developed, to directly monitor the diversity of Epstein-Barr Virus (EBV) carried in tissues and body fluids. Extensive inter-host diversity was observed, and in Human Immunodeficiency Virus (HlV)-infected hosts, EBV diversity could be demonstrated inter-compartmentally, even at sites that were anatomically proximate. In addition, a shift in tissue distribution of EBV-genotypes in hosts co-infected by HIV, was observed. It is suggested that the tongue, in HIV-infected persons, is hematogenously superinfected by Z2 variants of EBV, which are reported to preferentially carried by peripheral blood and possess 2 copies of a 29-base pair (bp) repeat in the BZLF-1 gene, and that this may play a role in the eventual appearance of Oral Hairy Leukoplakia (OHL). In United Kingdom, an increasing number of dental students and practitioners were found to be willing to provide dental care for HIV-infected persons. However, their knowledge about HIV infection when tested, was found to be incomplete. Finally, the prevalence of HIV among dental out-patients in an inner- city Dental Hospital in London was found to be 0.4%, using a serological diagnostic test.

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