UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evaluation of Causality Between ADHD and Parkinson’s Disease: Mendelian Randomization study

Li, GH-Y; Ge, GM; Cheung, C-L; Ip, P; Coghill, D; Wong, I; (2020) Evaluation of Causality Between ADHD and Parkinson’s Disease: Mendelian Randomization study. European Neuropsychopharmacology , 37 pp. 49-63. 10.1016/j.euroneuro.2020.06.001. Green open access

[thumbnail of Supplementary Material]
Preview
Image (Supplementary Material)
Fig1_MR_submit.jpg - Accepted Version

Download (260kB) | Preview
[thumbnail of Supplementary Material]
Preview
Image (Supplementary Material)
SuppFig1_Submit.jpg - Accepted Version

Download (151kB) | Preview
[thumbnail of Supplementary Material]
Preview
Image (Supplementary Material)
SuppFig2_Submit.jpg - Accepted Version

Download (165kB) | Preview
[thumbnail of Supplementary Material] Spreadsheet (Supplementary Material)
SuppTables_rev_Submit.xlsx - Accepted Version

Download (85kB)
[thumbnail of Accepted Manuscript]
Preview
Text (Accepted Manuscript)
Wong_Evaluation of Causality Between ADHD and Parkinson’s Disease_AAM.pdf - Accepted Version

Download (657kB) | Preview

Abstract

In a retrospective cohort study, patients with attention-deficit hyperactivity disorder (ADHD) and psychostimulant prescription were associated with increased risk of Parkinson's disease (PD). It is unclear whether ADHD per se or psychostimulant prescription is associated with PD. We aim to determine if genetic correlation or/and causal association exists between ADHD and PD using summary statistics obtained from the largest meta-analysis of genome-wide association studies of ADHD (20,183 cases; 35,191 controls) and PD (26,421 cases; 442,271 controls). Genetic correlation was tested between ADHD and PD by linkage disequilibrium score regression. Causal estimate was assessed by inverse-variance weighted (IVW) method as the main mendelian randomization analysis, with sensitivity analyses to detect horizontal pleiotropy. Weak and inverse genetic correlation existed between ADHD and PD (r=-0.100;SE=0.045;P = 0.026). Univariable IVW analysis with 10 and 77 genetic instruments respectively revealed null association for ADHD with PD (OR=0.930 per doubling in odds of ADHD; 95% CI:0.792–1.092) and PD with ADHD (OR=0.986 per doubling in odds of PD; 95% CI:0.956–1.015). Multivariable IVW analyses adjusted for BMI/smoking also revealed null association of ADHD with PD. Using 58 PD-associated genetic instruments, multivariable IVW analysis with/without adjustment for BMI/smoking suggested a weak and inverse causal association for PD on ADHD, but cautious interpretation is required. This well-powered study did not support causality between ADHD and PD. The observed positive association between ADHD and PD is more likely to be caused by unmeasured confounders. As psychostimulant use is associated with high risk of early-onset PD, future research should focus on this area.

Type: Article
Title: Evaluation of Causality Between ADHD and Parkinson’s Disease: Mendelian Randomization study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.euroneuro.2020.06.001
Publisher version: https://doi.org/10.1016/j.euroneuro.2020.06.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: https://discovery.ucl.ac.uk/id/eprint/10099663
Downloads since deposit
1,312Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item